SERTAD1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60410
Background:
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
Alternative Name:
SERTA domain-containing protein 1, CDK4-binding protein p34SEI1, SEI-1, Transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, SEI1
Application Dilution: WB: 1:500~1:1000
Specificity: SERTAD1 polyclonal antibody detects endogenous levels of SERTAD1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SERTAD1.
MW: ~ 25 kDa
Swis Prot.: Q9UHV2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
Alternative Name:
SERTA domain-containing protein 1, CDK4-binding protein p34SEI1, SEI-1, Transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, SEI1
Application Dilution: WB: 1:500~1:1000
Specificity: SERTAD1 polyclonal antibody detects endogenous levels of SERTAD1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SERTAD1.
MW: ~ 25 kDa
Swis Prot.: Q9UHV2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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