SETD7/Set7 monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO13580
Catalog Number: AC-ABO13580
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Description: Anti-SETD7/Set7 Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation..
Other Names: Histone-lysine N-methyltransferase SETD7, 2.1.1.364 {ECO:0000255|PROSITE-ProRule:PRU00910, ECO:0000269|PubMed:12540855}, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7
Clone Name(s):
Clone: ABA-19
Subcellular Localization: Nucleus. Chromosome.
Tissue Specificity: Widely expressed. Expressed in pancreatic islets.
Gene ID: 80854
Immunogen: A synthesized peptide derived from human SETD7
Calculated MW: 40721
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation..
Other Names: Histone-lysine N-methyltransferase SETD7, 2.1.1.364 {ECO:0000255|PROSITE-ProRule:PRU00910, ECO:0000269|PubMed:12540855}, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7
Clone Name(s):
Clone: ABA-19
Subcellular Localization: Nucleus. Chromosome.
Tissue Specificity: Widely expressed. Expressed in pancreatic islets.
Gene ID: 80854
Immunogen: A synthesized peptide derived from human SETD7
Calculated MW: 40721
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
| Is Featured? | No |
|---|
Write Your Own Review