SETD8 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7521
Background:
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance ofproper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382',leading to repress p53/TP53-target genes.
Alternative Name:
H4 K20 HMTase, H4 K20 specific histone methyltransferase, H4-K20-HMTase SETD8, Histone H4 K20 methyltransferase, Histone lysine N methyltransferase H4 lysine 20 specific, Histone-lysine N-methyltransferase, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, N-lysine methyltransferase SETD8, Pr SET 7, Pr SET7, PR-Set7, PR/SET domain containing protein 07, PR/SET domain containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PrSET7, SET 07, SET 8, SET domain containing (lysine methyltransferase) 8, SET domain containing 8, SET domain containing lysine methyltransferase 8, SET domain containing protein 8, SET domain-containing protein 8, SET07, SET8, SET9, SETD 8, setd8, SETD8_HUMAN,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: SETD8 polyclonal antibody detects endogenous levels of SETD8 protein.
Immunogen:
Recombinant full length Human SETD8.
MW: ~43 kDa
Swis Prot.: Q9NQR1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance ofproper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382',leading to repress p53/TP53-target genes.
Alternative Name:
H4 K20 HMTase, H4 K20 specific histone methyltransferase, H4-K20-HMTase SETD8, Histone H4 K20 methyltransferase, Histone lysine N methyltransferase H4 lysine 20 specific, Histone-lysine N-methyltransferase, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, N-lysine methyltransferase SETD8, Pr SET 7, Pr SET7, PR-Set7, PR/SET domain containing protein 07, PR/SET domain containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PrSET7, SET 07, SET 8, SET domain containing (lysine methyltransferase) 8, SET domain containing 8, SET domain containing lysine methyltransferase 8, SET domain containing protein 8, SET domain-containing protein 8, SET07, SET8, SET9, SETD 8, setd8, SETD8_HUMAN,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: SETD8 polyclonal antibody detects endogenous levels of SETD8 protein.
Immunogen:
Recombinant full length Human SETD8.
MW: ~43 kDa
Swis Prot.: Q9NQR1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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