SETDB1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7938
Background:
ERG-associated protein with SET domain (ESET), also designated Histone H3-K9 methyltransferase 4 or SET domain bifurcated 1, is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
Alternative Name:
ERG-associated protein with SET domain, ESET, H3 K9 HMTase 4, H3 lysine 9 specific 4, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3 K9 methyltransferase 4,Histone H3-K9 methyltransferase 4, Histone lysine N methyltransferase, Histone-lysine N-methyltransferase SETDB1, KG1T, KMT1E, Lysine N-methyltransferase 1E, MGC90670, mKIAA0067, SET domain bifurcated 1, Set domain protein, bifurcated, 1, SETB, SETB1_HUMAN, SETDB1, Similar to DNA topoisomerase II,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: SETDB1 polyclonal antibody detects endogenous levels of SETDB1 protein.
Immunogen:
Recombinant full length Human SETDB1.
MW: ~ 155 kDa
Swis Prot.: Q15047
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ERG-associated protein with SET domain (ESET), also designated Histone H3-K9 methyltransferase 4 or SET domain bifurcated 1, is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
Alternative Name:
ERG-associated protein with SET domain, ESET, H3 K9 HMTase 4, H3 lysine 9 specific 4, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3 K9 methyltransferase 4,Histone H3-K9 methyltransferase 4, Histone lysine N methyltransferase, Histone-lysine N-methyltransferase SETDB1, KG1T, KMT1E, Lysine N-methyltransferase 1E, MGC90670, mKIAA0067, SET domain bifurcated 1, Set domain protein, bifurcated, 1, SETB, SETB1_HUMAN, SETDB1, Similar to DNA topoisomerase II,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: SETDB1 polyclonal antibody detects endogenous levels of SETDB1 protein.
Immunogen:
Recombinant full length Human SETDB1.
MW: ~ 155 kDa
Swis Prot.: Q15047
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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