SETMAR polyclonal, anti-human
€388.00
In stock
SKU
BS8398
Background:
SETMAR (SET domain and mariner transposase fusion gene-containing protein), also known as METNASE or Hsmar1, is a ubiquitously expressed fusion protein with histone-lysine N-methyltransferase activity and DNA-binding, DNA-looping and DNA-cleavage activities. Localizing to the nucleus, SETMAR contains one N-terminal SET domain which facilitates the histone-lysine methyltransferase activity (at H3-Lys4 and H3-Lys36) and a C-terminal transposase domain which is responsible for the DNA-binding, -looping and -cleavage activities. Both domains are essential for the proper function of SETMAR. SETMAR specifically functions in DNA repair but, on its own, SETMAR can only bind to 5’-TIR (terminal inverted repeats) in DNA. For interactions with non-TIR DNA, SETMAR (via its SET domain) binds to and forms a stable complex with the pre-mRNA processing protein PRP19. Due to alternative splicing events, two isoforms exist.
Alternative Name:
Histone-lysine N-methyltransferase SETMAR, SET domain and mariner transposase fusion gene-containing protein, HsMar1, Metnase, SETMAR
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: SETMAR polyclonal antibody detects endogenous levels of SETMAR protein.
Immunogen:
Recombinant full length Human SETMAR.
MW: ~ 78 kDa
Swis Prot.: Q53H47
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SETMAR (SET domain and mariner transposase fusion gene-containing protein), also known as METNASE or Hsmar1, is a ubiquitously expressed fusion protein with histone-lysine N-methyltransferase activity and DNA-binding, DNA-looping and DNA-cleavage activities. Localizing to the nucleus, SETMAR contains one N-terminal SET domain which facilitates the histone-lysine methyltransferase activity (at H3-Lys4 and H3-Lys36) and a C-terminal transposase domain which is responsible for the DNA-binding, -looping and -cleavage activities. Both domains are essential for the proper function of SETMAR. SETMAR specifically functions in DNA repair but, on its own, SETMAR can only bind to 5’-TIR (terminal inverted repeats) in DNA. For interactions with non-TIR DNA, SETMAR (via its SET domain) binds to and forms a stable complex with the pre-mRNA processing protein PRP19. Due to alternative splicing events, two isoforms exist.
Alternative Name:
Histone-lysine N-methyltransferase SETMAR, SET domain and mariner transposase fusion gene-containing protein, HsMar1, Metnase, SETMAR
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: SETMAR polyclonal antibody detects endogenous levels of SETMAR protein.
Immunogen:
Recombinant full length Human SETMAR.
MW: ~ 78 kDa
Swis Prot.: Q53H47
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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