SF3B1 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13754a
Background:
This gene encodes subunit 1 of the splicing factor 3bprotein complex. Splicing factor 3b, together with splicing factor3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3acomplex binds pre-mRNA upstream of the intron's branch site in asequence independent manner and may anchor the U2 snRNP to thepre-mRNA. Splicing factor 3b is also a component of the minorU12-type spliceosome. The carboxy-terminal two-thirds of subunit 1have 22 non-identical, tandem HEAT repeats that form rod-like,helical structures. Alternative splicing results in multipletranscript variants encoding different isoforms. [provided byRefSeq].
Other Names:
Splicing factor 3B subunit 1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155, SF3B1, SAP155
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13754a was selected from the N-term region of SF3B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SF3B1 {ECO:0000303|PubMed:30567737, ECO:0000312|HGNC:HGNC:10768}
Gene ID: 23451
Primary Accession: O75533
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes subunit 1 of the splicing factor 3bprotein complex. Splicing factor 3b, together with splicing factor3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3acomplex binds pre-mRNA upstream of the intron's branch site in asequence independent manner and may anchor the U2 snRNP to thepre-mRNA. Splicing factor 3b is also a component of the minorU12-type spliceosome. The carboxy-terminal two-thirds of subunit 1have 22 non-identical, tandem HEAT repeats that form rod-like,helical structures. Alternative splicing results in multipletranscript variants encoding different isoforms. [provided byRefSeq].
Other Names:
Splicing factor 3B subunit 1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155, SF3B1, SAP155
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13754a was selected from the N-term region of SF3B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SF3B1 {ECO:0000303|PubMed:30567737, ECO:0000312|HGNC:HGNC:10768}
Gene ID: 23451
Primary Accession: O75533
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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