SFRS1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6851
Background:
SF2/ASF is a member of the Ser-Arg-rich (SR) protein family of highly conserved nuclear phosphoproteins involved in pre-mRNA splicing. Besides its role in nuclear pre-mRNA splicing, SF2/ASF has been shown to shuttle between the nucleus and cytoplasm, suggesting additional roles in mRNA transport and cytoplasmic events. SF2/ASF associates with translating ribosomes and stimulates translation. It also activates translation initiation by suppressing the activity of 4E-BP1, which is mediated by SF2/ASF association with mTOR and the phosphatase PP2A. More recent studies have demonstrated a role for SF2/ASF in microRNA processing.
Alternative Name:
ASF, MGC5228, SF2, SF2p33, SRp30a,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: SFRS1 polyclonal antibody detects endogenous levels of SFRS1 protein.
Immunogen:
Recombinant full length Human SFRS1.
MW: ~ 27 kDa
Swis Prot.: Q07955
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SF2/ASF is a member of the Ser-Arg-rich (SR) protein family of highly conserved nuclear phosphoproteins involved in pre-mRNA splicing. Besides its role in nuclear pre-mRNA splicing, SF2/ASF has been shown to shuttle between the nucleus and cytoplasm, suggesting additional roles in mRNA transport and cytoplasmic events. SF2/ASF associates with translating ribosomes and stimulates translation. It also activates translation initiation by suppressing the activity of 4E-BP1, which is mediated by SF2/ASF association with mTOR and the phosphatase PP2A. More recent studies have demonstrated a role for SF2/ASF in microRNA processing.
Alternative Name:
ASF, MGC5228, SF2, SF2p33, SRp30a,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: SFRS1 polyclonal antibody detects endogenous levels of SFRS1 protein.
Immunogen:
Recombinant full length Human SFRS1.
MW: ~ 27 kDa
Swis Prot.: Q07955
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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