SFRS8 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5952
Background:
SWAP (suppressor of white apricot protein homolog), also known as SFRS8 (splicing factor, arginine/serine-rich 8), is the 951 amino acid human homolog of a Drosophilia splicing protein. Localized to the nucleus, SWAP contains two SURP repeats through which it is thought to mediate splicing events, possibly regulating the alternative splicing of Fibronectin and CD45RC. SWAP regulates its own expression levels (via control of splicing in its first two introns) and may act in tandem with other arginine/serine-rich splicing factors to control protein expression. The gene encoding SWAP is located on a region of chromosome 12 that is related to asthma susceptibility, possibly indicating a role for SWAP in the development of asthma. Multiple isoforms of SWAP exist due to alternative splicing events.
Alternative Name:
Splicing factor, suppressor of white-apricot homolog, Splicing factor, arginine/serine-rich 8, Suppressor of white apricot protein homolog, SFSWAP, SFRS8, SWAP
Application Dilution: WB: 1:500~1:1000
Specificity: SFRS8 polyclonal antibody detects endogenous levels of SFRS8 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 251-296 of Human SFRS8.
MW: ~ 105 kDa
Swis Prot.: Q12872
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SWAP (suppressor of white apricot protein homolog), also known as SFRS8 (splicing factor, arginine/serine-rich 8), is the 951 amino acid human homolog of a Drosophilia splicing protein. Localized to the nucleus, SWAP contains two SURP repeats through which it is thought to mediate splicing events, possibly regulating the alternative splicing of Fibronectin and CD45RC. SWAP regulates its own expression levels (via control of splicing in its first two introns) and may act in tandem with other arginine/serine-rich splicing factors to control protein expression. The gene encoding SWAP is located on a region of chromosome 12 that is related to asthma susceptibility, possibly indicating a role for SWAP in the development of asthma. Multiple isoforms of SWAP exist due to alternative splicing events.
Alternative Name:
Splicing factor, suppressor of white-apricot homolog, Splicing factor, arginine/serine-rich 8, Suppressor of white apricot protein homolog, SFSWAP, SFRS8, SWAP
Application Dilution: WB: 1:500~1:1000
Specificity: SFRS8 polyclonal antibody detects endogenous levels of SFRS8 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 251-296 of Human SFRS8.
MW: ~ 105 kDa
Swis Prot.: Q12872
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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