SHC1 (clone 2F7C7), anti-human, mouse
€0.00
In stock
SKU
BT-MCA3526
Catalog Number: BT-MCA3526
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human, mouse
Application(s): WB, ICC, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human, mouse
Application(s): WB, ICC, FCM
Datasheet
Request Information
Background:
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Research Area: Neuroscience
Synonyms: SHC, SHCA
Immunogen: Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
Storage:
4°C|-20°C for long term storage
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Research Area: Neuroscience
Synonyms: SHC, SHCA
Immunogen: Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
Storage:
4°C|-20°C for long term storage
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