SHH Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP12343c
Background:
This gene encodes a protein that is instrumental inpatterning the early embryo. It has been implicated as the keyinductive signal in patterning of the ventral neural tube, theanterior-posterior limb axis, and the ventral somites. Of threehuman proteins showing sequence and functional similarity to thesonic hedgehog protein of Drosophila, this protein is the mostsimilar. The protein is made as a precursor that isautocatalytically cleaved; the N-terminal portion is soluble andcontains the signalling activity while the C-terminal portion isinvolved in precursor processing. More importantly, the C-terminalproduct covalently attaches a cholesterol moiety to the N-terminalproduct, restricting the N-terminal product to the cell surface andpreventing it from freely diffusing throughout the developingembryo. Defects in this protein or in its signalling pathway are acause of holoprosencephaly (HPE), a disorder in which thedeveloping forebrain fails to correctly separate into right andleft hemispheres. HPE is manifested by facial deformities. It isalso thought that mutations in this gene or in its signallingpathway may be responsible for VACTERL syndrome, which ischaracterized by vertebral defects, anal atresia, tracheoesophagealfistula with esophageal atresia, radial and renal dysplasia,cardiac anomalies, and limb abnormalities. Additionally, mutationsin a long range enhancer located approximately 1 megabase upstreamof this gene disrupt limb patterning and can result in preaxialpolydactyly.
Other Names:
Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product, SHH
Gene Name: SHH (HGNC:10848)
Gene ID: 6469
Primary Accession: Q15465
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a protein that is instrumental inpatterning the early embryo. It has been implicated as the keyinductive signal in patterning of the ventral neural tube, theanterior-posterior limb axis, and the ventral somites. Of threehuman proteins showing sequence and functional similarity to thesonic hedgehog protein of Drosophila, this protein is the mostsimilar. The protein is made as a precursor that isautocatalytically cleaved; the N-terminal portion is soluble andcontains the signalling activity while the C-terminal portion isinvolved in precursor processing. More importantly, the C-terminalproduct covalently attaches a cholesterol moiety to the N-terminalproduct, restricting the N-terminal product to the cell surface andpreventing it from freely diffusing throughout the developingembryo. Defects in this protein or in its signalling pathway are acause of holoprosencephaly (HPE), a disorder in which thedeveloping forebrain fails to correctly separate into right andleft hemispheres. HPE is manifested by facial deformities. It isalso thought that mutations in this gene or in its signallingpathway may be responsible for VACTERL syndrome, which ischaracterized by vertebral defects, anal atresia, tracheoesophagealfistula with esophageal atresia, radial and renal dysplasia,cardiac anomalies, and limb abnormalities. Additionally, mutationsin a long range enhancer located approximately 1 megabase upstreamof this gene disrupt limb patterning and can result in preaxialpolydactyly.
Other Names:
Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product, SHH
Gene Name: SHH (HGNC:10848)
Gene ID: 6469
Primary Accession: Q15465
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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