SHH (clone 8G3), anti-human
€478.00
In stock
SKU
253016
Protein Family: Peptidases, Transcription Factors
Pathway and Disease: Signal Transduction, Cancers, Development and Behavior, Nervous and Sensory Systems, Transcription
Description:
SHH (Sonic hedgehog) is member of the hedgehog signaling pathway. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Sonic hedgehog is an intercellular signal essential for a variety of patterning events during development, such as ventral cell fate in the neural tube and somites, and for patterning of the anterior-posterior axis of the developing limb bud. Defects in sonic hedgehog has been implicated in eye formation disorders and holoprosencephaly, the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres.
Alternate Names: Sonic hedgehog protein, SHH, HHG-1, TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5
Application Notes: WB: 1:200-1:1000
Accession No.: Q15465
Antigen: Purified recombinant fragment of human SHH expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signal Transduction, Cancers, Development and Behavior, Nervous and Sensory Systems, Transcription
Description:
SHH (Sonic hedgehog) is member of the hedgehog signaling pathway. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Sonic hedgehog is an intercellular signal essential for a variety of patterning events during development, such as ventral cell fate in the neural tube and somites, and for patterning of the anterior-posterior axis of the developing limb bud. Defects in sonic hedgehog has been implicated in eye formation disorders and holoprosencephaly, the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres.
Alternate Names: Sonic hedgehog protein, SHH, HHG-1, TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5
Application Notes: WB: 1:200-1:1000
Accession No.: Q15465
Antigen: Purified recombinant fragment of human SHH expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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