SHIP (Phospho-Y1020) polyclonal, anti-human

Background:
The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.

Alternative Name:
SIP-145, SH2 domain-containing inositol phosphatase 1, SHIP-1, hp51CN, INPP5D, SHIP, SHIP1, Inositol polyphosphate 5 phosphatase of 145kDa, 4, 5-trisphosphate 5-phosphatase 1, hp51CN, Inositol polyphosphate 5 phosphatase 145kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP5D, MGC104855, MGC142140, MGC142142, p150Ship, Phosphatidylinositol 3, 4, 5 trisphosphate 5 phosphatase 1, Phosphatidylinositol-3, SH2 containing inositol phosphatase isoform b, SH2 domain containing inositol 5' phosphatase 1, SH2 domain containing inositol phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5''-phosphatase 1, SHIP-1, SHIP1, SHIP1, Signaling inositol polyphosphate 5 phosphatase SIP 145, SIP-145, SIP145,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200

Specificity: SHIP (Phospho-Y1020) polyclonal antibody detects endogenous levels of SHIP protein only when phosphorylated at Y1020.

Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Tyr1020 of human SHIP.

MW: 133 kDa

Swiss-Prot: Q92835(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.