BATF2 polyclonal, anti-human, mouse, rat

Background:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.

Other Names:
Basic leucine zipper transcriptional factor ATF-like 2, B-ATF-2, Suppressor of AP-1 regulated by IFN, SARI, BATF2

Antigen Type: synthetic peptide

Antigen Type: BATF2
Gene ID: 116071
Primary Accession: Q8N1L9