SHMT2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6257
Background:
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
Alternative Name:
GLYA, Glycine hydroxymethyltransferase, Serine hydroxymethyltransferase 2 (mitochondrial), Serine hydroxymethyltransferase mitochondrial, Serine methylase, SHMT 2, SHMT,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: SHMT2 polyclonal antibody detects endogenous levels of SHMT2 protein.
Immunogen:
Recombinant full length Human SHMT2.
MW: ~ 56 kDa
Swis Prot.: P34897
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
Alternative Name:
GLYA, Glycine hydroxymethyltransferase, Serine hydroxymethyltransferase 2 (mitochondrial), Serine hydroxymethyltransferase mitochondrial, Serine methylase, SHMT 2, SHMT,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: SHMT2 polyclonal antibody detects endogenous levels of SHMT2 protein.
Immunogen:
Recombinant full length Human SHMT2.
MW: ~ 56 kDa
Swis Prot.: P34897
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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