Siah-1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7222
Background:
SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth.
Alternative Name:
SIAH1, HUMSIAH. Siah-1. Siah-1a. hSIAH1
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: Siah-1 polyclonal antibody detects endogenous levels of Siah-1 protein.
Immunogen:
Recombinant full length Human Siah-1.
MW: ~ 40 kDa
Swis Prot.: Q8IUQ4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth.
Alternative Name:
SIAH1, HUMSIAH. Siah-1. Siah-1a. hSIAH1
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: Siah-1 polyclonal antibody detects endogenous levels of Siah-1 protein.
Immunogen:
Recombinant full length Human Siah-1.
MW: ~ 40 kDa
Swis Prot.: Q8IUQ4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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