Signal peptide peptidase-like 2B (SPPL2b) Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP6312b
Background:
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. Several presenilin homologues/SPP-like proteins (PSHs/SPPL) have been identified. Unlike the ER localization of SPP and other SPPL proteins, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes.
Other Names:
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6312b was selected from the Center region of human SPPL2b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Gene ID: 56928
Primary Accession: Q8TCT7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. Several presenilin homologues/SPP-like proteins (PSHs/SPPL) have been identified. Unlike the ER localization of SPP and other SPPL proteins, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes.
Other Names:
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6312b was selected from the Center region of human SPPL2b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Gene ID: 56928
Primary Accession: Q8TCT7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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