Signal peptide peptidase-like 2B (SPPL2b) Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP6311a
Background:
By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2000) cloned KIAA1532. The deduced protein contains 601 amino acids. RT-PCR ELISA detected high expression in all tissues and specific brain regions examined. By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned IMP4. The deduced protein contains 592 amino acids. Like other IMP proteins, IMP4 contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
Other Names:
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6311a was selected from the N-term region of human SPPL2b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Gene ID: 56928
Primary Accession: Q8TCT7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2000) cloned KIAA1532. The deduced protein contains 601 amino acids. RT-PCR ELISA detected high expression in all tissues and specific brain regions examined. By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned IMP4. The deduced protein contains 592 amino acids. Like other IMP proteins, IMP4 contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
Other Names:
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6311a was selected from the N-term region of human SPPL2b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Gene ID: 56928
Primary Accession: Q8TCT7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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