SIRPA Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17203b
Background:
The protein encoded by this gene is a member of thesignal-regulatory-protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.This protein can be phosphorylated by tyrosine kinases. Thephospho-tyrosine residues of this PTP have been shown to recruitSH2 domain containing tyrosine phosphatases (PTP), and serve assubstrates of PTPs. This protein was found to participate in signaltransduction mediated by various growth factor receptors. CD47 hasbeen demonstrated to be a ligand for this receptor protein. Thisgene and its product share very high similarity with several othermembers of the SIRP family. These related genes are located inclose proximity to each other on chromosome 20p13. Multiplealternatively spliced transcript variants have been determined forthis gene.
Other Names:
Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Gene Name: SIRPA
Gene ID: 140885
Primary Accession: P78324
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of thesignal-regulatory-protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.This protein can be phosphorylated by tyrosine kinases. Thephospho-tyrosine residues of this PTP have been shown to recruitSH2 domain containing tyrosine phosphatases (PTP), and serve assubstrates of PTPs. This protein was found to participate in signaltransduction mediated by various growth factor receptors. CD47 hasbeen demonstrated to be a ligand for this receptor protein. Thisgene and its product share very high similarity with several othermembers of the SIRP family. These related genes are located inclose proximity to each other on chromosome 20p13. Multiplealternatively spliced transcript variants have been determined forthis gene.
Other Names:
Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Gene Name: SIRPA
Gene ID: 140885
Primary Accession: P78324
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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