SIRT1 (clone 2G10-F4-D9), anti-human

Background:
This gene encodes a member of the sirtuin family of proteins,homologs to the yeast Sir2 protein.Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes.The functions of human sirtuins have not yet been determined;however,yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.The protein encoded by this gene is included in class I of the sirtuin family.Alternative splicing results in multiple transcript variants.[provided by RefSeq,Dec 2008]

Synonyms: SIR2, SIR2alpha, SIR2L1

Cellular Location: Cytoplasm Mitochondrion Nucleus Nucleus PML body

Immunogen:
Purified recombinant human SIRT1 protein fragments expressed in E.coli.

Gene Symbol: SIRT1

Gene ID: 23411

Swiss prot: Q96EB6

Calculated MW: 120kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.