SIRT6 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6245a
Background:
SIRT6 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Other Names:
NAD-dependent protein deacetylase sirtuin-6, 351-, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6245a was selected from the C-term region of human SIRT6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SIRT6 {ECO:0000303|PubMed:10873683, ECO:0000312|HGNC:HGNC:14934}
Gene ID: 51548
Primary Accession: Q8N6T7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
SIRT6 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Other Names:
NAD-dependent protein deacetylase sirtuin-6, 351-, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6245a was selected from the C-term region of human SIRT6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SIRT6 {ECO:0000303|PubMed:10873683, ECO:0000312|HGNC:HGNC:14934}
Gene ID: 51548
Primary Accession: Q8N6T7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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