SIRT6 monoclonal, anti-human

Description: Anti-SIRT6 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human.

Protein Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD (+) in the absence of acetylated substrate..

Other Names: NAD-dependent protein deacylase sirtuin-6, 2.3.1.-, NAD-dependent protein deacetylase sirtuin-6, 2.3.1.286 {ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:23892288, ECO:0000269|PubMed:24052263, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27322069}, Protein mono-ADP-ribosyltransferase sirtuin-6, 2.4.2.-, Regulatory protein SIR2 homolog 6, hSIRT6, SIR2-like protein 6, SIRT6 {ECO:0000303|PubMed:10873683, ECO:0000312|HGNC:HGNC:14934}

Clone Name(s):
Clone: HBA-19

Subcellular Localization: Nucleus, nucleoplasm. Predominantly nuclear. Associated with telomeric heterochromatin regions.

Gene ID: 51548

Immunogen: A synthesized peptide derived from human SIRT6

Calculated MW: 39119

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.