Sirtuin 1 (clone SR119-1AG), anti-human
€204.00
In stock
SKU
ARP-23-A0081
Catalog Number: 23-A0081
Size: 25 µg
Isotype: Mouse IgG1 kappa
Size: 25 µg
Isotype: Mouse IgG1 kappa
Decription:
Sirtuin-1 is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Sirtuin-1 emerged as critical regulator of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Sirtuin-1 has been suggested as potential biomarker for tumorigenesis.
Synonyms: SIRT1, NAD-dependent Deacetylase Sirtuin-1, SIR2-like Protein 1, SIR2L1
Clone: SR119-1AG
Isotype: Mouse IgG1 kappa
Immunogen: Recombinant human sirtuin 1.
Reactivity: human
Specificity: Recognizes human sirtuin 1. Detects a band of ~78kDa by Western blot.
Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Applications:
ELISA: (direct and indirect: 1:2'000-1:5'000)
Western Blot: (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
Sirtuin-1 is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Sirtuin-1 emerged as critical regulator of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Sirtuin-1 has been suggested as potential biomarker for tumorigenesis.
Synonyms: SIRT1, NAD-dependent Deacetylase Sirtuin-1, SIR2-like Protein 1, SIR2L1
Clone: SR119-1AG
Isotype: Mouse IgG1 kappa
Immunogen: Recombinant human sirtuin 1.
Reactivity: human
Specificity: Recognizes human sirtuin 1. Detects a band of ~78kDa by Western blot.
Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Applications:
ELISA: (direct and indirect: 1:2'000-1:5'000)
Western Blot: (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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