Sirtuin 2 (clone S2R233-1), anti-human
€204.00
In stock
SKU
ARP-23-A0076
Catalog Number: 23-A0076
Size: 25 µg
Isotype: Mouse IgG2b kappa
Size: 25 µg
Isotype: Mouse IgG2b kappa
Decription:
Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.
Synonyms: SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2
Clone: S2R233-1
Isotype: Mouse IgG2b kappa
Immunogen: Recombinant human sirtuin 2.
Reactivity: human
Specificity: Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot.
Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Applications:
ELISA: (direct and indirect: 1:2'000-1:5'000)
Western Blot: (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.
Synonyms: SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2
Clone: S2R233-1
Isotype: Mouse IgG2b kappa
Immunogen: Recombinant human sirtuin 2.
Reactivity: human
Specificity: Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot.
Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Applications:
ELISA: (direct and indirect: 1:2'000-1:5'000)
Western Blot: (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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