Skp1 p19 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7223
Background:
Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.
Alternative Name:
p19A, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-2, OCP-II, Transcription elongation factor B, SIII, SKP1, EMC19, OCP2, SKP1A, TCEB1L
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Skp1 p19 polyclonal antibody detects endogenous levels of Skp1 p19 protein.
Immunogen:
Recombinant full length Human Skp1 p19.
MW: ~ 19 kDa
Swis Prot.: P63208
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.
Alternative Name:
p19A, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-2, OCP-II, Transcription elongation factor B, SIII, SKP1, EMC19, OCP2, SKP1A, TCEB1L
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Skp1 p19 polyclonal antibody detects endogenous levels of Skp1 p19 protein.
Immunogen:
Recombinant full length Human Skp1 p19.
MW: ~ 19 kDa
Swis Prot.: P63208
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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