SKP2 (clone 6G9D10), anti-human
€478.00
In stock
SKU
252839
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Cancers, Cell Growth and Death, Folding, Sorting and Degradation, Signaling Molecules and Interaction
Description:
Skp2 (S-phase kinase-associated protein 2) is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Skp2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition.
Alternate Names: Skp2, S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, FBXL1
Application Notes: WB: 1:500-1:2000
Accession No.: Q13309
Antigen: Purified recombinant fragment of SKP2(aa1-130) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Cell Growth and Death, Folding, Sorting and Degradation, Signaling Molecules and Interaction
Description:
Skp2 (S-phase kinase-associated protein 2) is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Skp2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition.
Alternate Names: Skp2, S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, FBXL1
Application Notes: WB: 1:500-1:2000
Accession No.: Q13309
Antigen: Purified recombinant fragment of SKP2(aa1-130) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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