SLC12A1 antibody (clone 4H4), anti-human
€435.00
In stock
SKU
AC-AT3901a
Catalog Number: AC-AT3901a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT3901a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT3901a">Request Information
Background:
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Other Names:
Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, SLC12A1, NKCC2
Antigen Type:
Recombinant Protein
Gene Name: SLC12A1
Gene ID: 6557
NCBI Accession: NP_000329.2;NP_001171761.1
Primary Accession: Q13621
Other Accession: NM_000338
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Other Names:
Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, SLC12A1, NKCC2
Antigen Type:
Recombinant Protein
Gene Name: SLC12A1
Gene ID: 6557
NCBI Accession: NP_000329.2;NP_001171761.1
Primary Accession: Q13621
Other Accession: NM_000338
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review