SLC12A3 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP12230a
Background:
This gene encodes a renal thiazide-sensitivesodium-chloride cotransporter that is important for electrolytehomeostasis. This cotransporter mediates sodium and chloridereabsorption in the distal convoluted tubule. Mutations in thisgene cause Gitelman syndrome, a disease similar to Bartter'ssyndrome, that is characterized by hypokalemic alkalosis combinedwith hypomagnesemia, low urinary calcium, and increased reninactivity associated with normal blood pressure. This cotransporteris the target for thiazide diuretics that are used for treatinghigh blood pressure. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Solute carrier family 12 member 3, Na-Cl cotransporter, NCC, Na-Cl symporter, Thiazide-sensitive sodium-chloride cotransporter, SLC12A3, NCC, TSC
Gene Name: SLC12A3 {ECO:0000303|PubMed:8812482, ECO:0000312|HGNC:HGNC:10912}
Gene ID: 6559
Primary Accession: P55017
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a renal thiazide-sensitivesodium-chloride cotransporter that is important for electrolytehomeostasis. This cotransporter mediates sodium and chloridereabsorption in the distal convoluted tubule. Mutations in thisgene cause Gitelman syndrome, a disease similar to Bartter'ssyndrome, that is characterized by hypokalemic alkalosis combinedwith hypomagnesemia, low urinary calcium, and increased reninactivity associated with normal blood pressure. This cotransporteris the target for thiazide diuretics that are used for treatinghigh blood pressure. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Solute carrier family 12 member 3, Na-Cl cotransporter, NCC, Na-Cl symporter, Thiazide-sensitive sodium-chloride cotransporter, SLC12A3, NCC, TSC
Gene Name: SLC12A3 {ECO:0000303|PubMed:8812482, ECO:0000312|HGNC:HGNC:10912}
Gene ID: 6559
Primary Accession: P55017
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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