SLC19A1 Blocking Peptide (Center)

Background:
Transport of folate compounds into mammalian cells canoccur via receptor-mediated (see MIM 136430) or carrier-mediatedmechanisms. A functional coordination between these 2 mechanismshas been proposed to be the method of folate uptake in certain celltypes. Methotrexate (MTX) is an antifolate chemotherapeutic agentthat is actively transported by the carrier-mediated uptake system.RFC1 plays a role in maintaining intracellular concentrations offolate.

Other Names:
Folate transporter 1, FOLT, Intestinal folate carrier 1, IFC-1, Placental folate transporter, Reduced folate carrier protein, RFC, Solute carrier family 19 member 1, SLC19A1, FLOT1, RFC1

Target/Specificity:
The synthetic peptide sequence is selected from aa 206-218 of HUMAN SLC19A1

Gene Name: SLC19A1 (HGNC:10937)

Gene ID: 6573
Primary Accession: P41440
Other Accession: NP_919231.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.