SLC25A12 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS5616
Background:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Alternative Name:
Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, ARALAR1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: SLC25A12 polyclonal antibody detects endogenous levels of SLC25A12 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 435-480 of Human SLC25A12.
MW: ~ 74 kDa
Swis Prot.: O75746
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Alternative Name:
Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, ARALAR1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: SLC25A12 polyclonal antibody detects endogenous levels of SLC25A12 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 435-480 of Human SLC25A12.
MW: ~ 74 kDa
Swis Prot.: O75746
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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