SLC25A13 polyclonal, anti-human
€388.00
In stock
SKU
BS7897
Background:
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
Alternative Name:
ARALAR2, Calcium binding mitochondrial carrier protein Aralar2, Calcium-binding mitochondrial carrier protein Aralar2, Citrin, CMC2_HUMAN, CTLN2, Ctrn, Mitochondrial aspartate glutamate carrier 2, RGD1565889, Slc25a13, Solute carrier family 25 (citrin) member 13, Solute carrier family 25 member 13 (citrin), Solute carrier family 25 member 13,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200
Specificity: SLC25A13 polyclonal antibody detects endogenous levels of SLC25A13 protein.
Immunogen:
Recombinant full length Human SLC25A13.
MW: ~ 74 kDa
Swis Prot.: Q9UJS0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
Alternative Name:
ARALAR2, Calcium binding mitochondrial carrier protein Aralar2, Calcium-binding mitochondrial carrier protein Aralar2, Citrin, CMC2_HUMAN, CTLN2, Ctrn, Mitochondrial aspartate glutamate carrier 2, RGD1565889, Slc25a13, Solute carrier family 25 (citrin) member 13, Solute carrier family 25 member 13 (citrin), Solute carrier family 25 member 13,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200
Specificity: SLC25A13 polyclonal antibody detects endogenous levels of SLC25A13 protein.
Immunogen:
Recombinant full length Human SLC25A13.
MW: ~ 74 kDa
Swis Prot.: Q9UJS0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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