SLC4A1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14828a
Background:
The protein encoded by this gene is part of the anionexchanger (AE) family and is expressed in the erythrocyte plasmamembrane, where it functions as a chloride/bicarbonate exchangerinvolved in carbon dioxide transport from tissues to lungs. Theprotein comprises two domains that are structurally andfunctionally distinct. The N-terminal 40kDa domain is located inthe cytoplasm and acts as an attachment site for the red cellskeleton by binding ankyrin. The glycosylated C-terminalmembrane-associated domain contains 12-14 membrane spanningsegments and carries out the stilbene disulphonate-sensitiveexchange transport of anions. The cytoplasmic tail at the extremeC-terminus of the membrane domain binds carbonic anhydrase II. Theencoded protein associates with the red cell membrane proteinglycophorin A and this association promotes the correct folding andtranslocation of the exchanger. This protein is predominantlydimeric but forms tetramers in the presence of ankyrin. Manymutations in this gene are known in man, and these mutations canlead to two types of disease: destabilization of red cell membraneleading to hereditary spherocytosis, and defective kidney acidsecretion leading to distal renal tubular acidosis. Other mutationsthat do not give rise to disease result in novel blood groupantigens, which form the Diego blood group system. Southeast Asianovalocytosis (SAO, Melanesian ovalocytosis) results from theheterozygous presence of a deletion in the encoded protein and iscommon in areas where Plasmodium falciparum malaria is endemic. Onenull mutation in this gene is known, resulting in very severeanemia and nephrocalcinosis.
Other Names:
Band 3 anion transport protein, Anion exchange protein 1, AE 1, Anion exchanger 1, Solute carrier family 4 member 1, CD233, SLC4A1, AE1, DI, EPB3
Gene Name: SLC4A1 (HGNC:11027)
Gene ID: 6521
Primary Accession: P02730
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is part of the anionexchanger (AE) family and is expressed in the erythrocyte plasmamembrane, where it functions as a chloride/bicarbonate exchangerinvolved in carbon dioxide transport from tissues to lungs. Theprotein comprises two domains that are structurally andfunctionally distinct. The N-terminal 40kDa domain is located inthe cytoplasm and acts as an attachment site for the red cellskeleton by binding ankyrin. The glycosylated C-terminalmembrane-associated domain contains 12-14 membrane spanningsegments and carries out the stilbene disulphonate-sensitiveexchange transport of anions. The cytoplasmic tail at the extremeC-terminus of the membrane domain binds carbonic anhydrase II. Theencoded protein associates with the red cell membrane proteinglycophorin A and this association promotes the correct folding andtranslocation of the exchanger. This protein is predominantlydimeric but forms tetramers in the presence of ankyrin. Manymutations in this gene are known in man, and these mutations canlead to two types of disease: destabilization of red cell membraneleading to hereditary spherocytosis, and defective kidney acidsecretion leading to distal renal tubular acidosis. Other mutationsthat do not give rise to disease result in novel blood groupantigens, which form the Diego blood group system. Southeast Asianovalocytosis (SAO, Melanesian ovalocytosis) results from theheterozygous presence of a deletion in the encoded protein and iscommon in areas where Plasmodium falciparum malaria is endemic. Onenull mutation in this gene is known, resulting in very severeanemia and nephrocalcinosis.
Other Names:
Band 3 anion transport protein, Anion exchange protein 1, AE 1, Anion exchanger 1, Solute carrier family 4 member 1, CD233, SLC4A1, AE1, DI, EPB3
Gene Name: SLC4A1 (HGNC:11027)
Gene ID: 6521
Primary Accession: P02730
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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