SLC5A8 Blocking Peptide (C-Term)

Background:
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Other Names:
Sodium-coupled monocarboxylate transporter 1, Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, Solute carrier family 5 member 8, SLC5A8 {ECO:0000312|EMBL:AAP46193.1}

Target/Specificity:
The synthetic peptide sequence is selected from aa 599-609 of HUMAN SLC5A8

Gene Name: SLC5A8 {ECO:0000312|EMBL:AAP46193.1}

Gene ID: 160728
Primary Accession: Q8N695
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.