Smac/Diablo monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO14084
Catalog Number: AC-ABO14084
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, IP, FC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, IP, FC
Datasheet
Request Information
Description: Anti-Smac/Diablo Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance..
Other Names: Diablo IAP-binding mitochondrial protein {ECO:0000312|HGNC:HGNC:21528}, Diablo homolog, mitochondrial {ECO:0000312|HGNC:HGNC:21528}, Direct IAP-binding protein with low pI {ECO:0000312|HGNC:HGNC:21528}, Second mitochondria-derived activator of caspase, Smac, Diablo IAP-binding mitochondrial protein, cleaved form, DIABLO (HGNC:21528)
Clone Name(s):
Clone: FGG-4
Subcellular Localization: Mitochondrion. Released into the cytosol when cells undergo apoptosis.
Tissue Specificity: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed..
Gene ID: 56616
Immunogen: A synthesized peptide derived from human Smac/Diablo
Calculated MW: 27131
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance..
Other Names: Diablo IAP-binding mitochondrial protein {ECO:0000312|HGNC:HGNC:21528}, Diablo homolog, mitochondrial {ECO:0000312|HGNC:HGNC:21528}, Direct IAP-binding protein with low pI {ECO:0000312|HGNC:HGNC:21528}, Second mitochondria-derived activator of caspase, Smac, Diablo IAP-binding mitochondrial protein, cleaved form, DIABLO (HGNC:21528)
Clone Name(s):
Clone: FGG-4
Subcellular Localization: Mitochondrion. Released into the cytosol when cells undergo apoptosis.
Tissue Specificity: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed..
Gene ID: 56616
Immunogen: A synthesized peptide derived from human Smac/Diablo
Calculated MW: 27131
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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