SMAD1 antibody (clone 2A1), anti-human, mouse, rat
€435.00
In stock
SKU
AC-AT3938a
Catalog Number: AC-AT3938a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, IFhttps://www.abcepta.com/products/pdf_download/AT3938a-SMAD1-Antibody-monoclonal-M04">Request Information AC-AT3938a">Request Information
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, IFhttps://www.abcepta.com/products/pdf_download/AT3938a-SMAD1-Antibody-monoclonal-M04">Request Information AC-AT3938a">Request Information
Background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Other Names:
Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1
Antigen Type:
Recombinant Protein
Gene Name: SMAD1
Gene ID: 4086
NCBI Accession: NP_001003688.1;NP_005891.1
Primary Accession: Q15797
Other Accession: BC001878
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Other Names:
Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1
Antigen Type:
Recombinant Protein
Gene Name: SMAD1
Gene ID: 4086
NCBI Accession: NP_001003688.1;NP_005891.1
Primary Accession: Q15797
Other Accession: BC001878
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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