SMAD1 Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP20141a
Background:
The protein encoded by this gene belongs to the SMAD, afamily of proteins similar to the gene products of the Drosophilagene 'mothers against decapentaplegic' (Mad) and the C. elegansgene Sma. SMAD proteins are signal transducers and transcriptionalmodulators that mediate multiple signaling pathways. This proteinmediates the signals of the bone morphogenetic proteins (BMPs),which are involved in a range of biological activities includingcell growth, apoptosis, morphogenesis, development and immuneresponses. In response to BMP ligands, this protein can bephosphorylated and activated by the BMP receptor kinase. Thephosphorylated form of this protein forms a complex with SMAD4,which is important for its function in the transcriptionregulation. This protein is a target for SMAD-specific E3 ubiquitinligases, such as SMURF1 and SMURF2, and undergoes ubiquitinationand proteasome-mediated degradation. Alternatively splicedtranscript variants encoding the same protein have been observed.
Other Names:
Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1
Target/Specificity:
The synthetic peptide sequence is selected from aa 14-26 of HUMAN SMAD1
Gene Name: SMAD1
Gene ID: 4086
Primary Accession: Q15797
Other Accession: O54835; Q9JIW5; O15198; Q9R1V3; P97454; Q99717; Q9W7E7; Q56I99; P97588; P70340; Q9I8V2; Q1JQA2; NP_005891.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene belongs to the SMAD, afamily of proteins similar to the gene products of the Drosophilagene 'mothers against decapentaplegic' (Mad) and the C. elegansgene Sma. SMAD proteins are signal transducers and transcriptionalmodulators that mediate multiple signaling pathways. This proteinmediates the signals of the bone morphogenetic proteins (BMPs),which are involved in a range of biological activities includingcell growth, apoptosis, morphogenesis, development and immuneresponses. In response to BMP ligands, this protein can bephosphorylated and activated by the BMP receptor kinase. Thephosphorylated form of this protein forms a complex with SMAD4,which is important for its function in the transcriptionregulation. This protein is a target for SMAD-specific E3 ubiquitinligases, such as SMURF1 and SMURF2, and undergoes ubiquitinationand proteasome-mediated degradation. Alternatively splicedtranscript variants encoding the same protein have been observed.
Other Names:
Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1
Target/Specificity:
The synthetic peptide sequence is selected from aa 14-26 of HUMAN SMAD1
Gene Name: SMAD1
Gene ID: 4086
Primary Accession: Q15797
Other Accession: O54835; Q9JIW5; O15198; Q9R1V3; P97454; Q99717; Q9W7E7; Q56I99; P97588; P70340; Q9I8V2; Q1JQA2; NP_005891.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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