Smad2 (clone ), anti-human, mouse, rat

Background:
Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.

Alternative Name:
MAD homolog 2, Mothers against DPP homolog 2, hMAD-2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2, Drosophila, homolog of, MADR2, hMAD-2, HsMAD2, JV18, JV18-1, JV181, MAD, MAD homolog 2, MAD Related Protein 2, Mad-related protein 2, MADH2, MADR2, MGC22139, MGC34440, Mother against DPP homolog 2, Mothers against decapentaplegic homolog 2, Mothers against decapentaplegic, Drosophila, homolog of, 2, Mothers against DPP homolog 2, OTTHUMP00000163489, Sma and Mad related protein 2, Sma- and Mad-related protein 2 MAD, SMAD 2, SMAD family member 2, SMAD, mothers against DPP homolog 2, SMAD2, SMAD2,

Application Dilution:
WB:1:500
IHC/ICC:1:50-1:200

Specificity: Smad2 monoclonal antibody detects endogenous levels of Smad2 protein.

Immunogen:
Recombinant protein

MW: 58 kDa

Swiss-Prot: Q15796(Human) Q62432(Mouse) O70436(Rat)

Purification & Purity:
ProG affinity purified

Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.