SMAD3 Monoclonal Antibody
€0.00
In stock
SKU
E-AB-22229
Catalog Number: E-AB-22229
Isotype: Mouse IgG, Clone: 1E8
Reactivity: human
Applications: IHC-p
Datasheet, Questions? Contact us!
Isotype: Mouse IgG, Clone: 1E8
Reactivity: human
Applications: IHC-p
Datasheet, Questions? Contact us!
Background:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem Cells
Synonyms:
DKFZP586N0721, DKFZp686J10186, hMAD 3, hMAD-3, hSMAD3, HSPC193, HST17436, JV15 2, JV15-2, JV152, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, Mad homolog JV15 2, Mad protein homolog, MAD, mothers against decapentaplegic homolog 3, Mad3, MADH 3, MADH3, MGC60396, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, Smad3, SMAD3
Immunogen: Synthetic Peptide of Smad3
Swissprot: P84022
Purification Method: Protein A purification
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Concentration: 1 mg/mL
Dilution: IHC 1:100-200
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem Cells
Synonyms:
DKFZP586N0721, DKFZp686J10186, hMAD 3, hMAD-3, hSMAD3, HSPC193, HST17436, JV15 2, JV15-2, JV152, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, Mad homolog JV15 2, Mad protein homolog, MAD, mothers against decapentaplegic homolog 3, Mad3, MADH 3, MADH3, MGC60396, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, Smad3, SMAD3
Immunogen: Synthetic Peptide of Smad3
Swissprot: P84022
Purification Method: Protein A purification
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Concentration: 1 mg/mL
Dilution: IHC 1:100-200
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
| Is Featured? | No |
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