SMAD4 antibody (clone 3B9), anti-human
€435.00
In stock
SKU
AC-AT3942a
Catalog Number: AC-AT3942a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
Request Information AC-AT3942a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
Request Information AC-AT3942a">Request Information
Background:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Other Names:
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4
Antigen Type:
Recombinant Protein
Gene Name: SMAD4
Gene ID: 4089
NCBI Accession: NP_005350.1
Primary Accession: Q13485
Other Accession: BC002379
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Other Names:
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4
Antigen Type:
Recombinant Protein
Gene Name: SMAD4
Gene ID: 4089
NCBI Accession: NP_005350.1
Primary Accession: Q13485
Other Accession: BC002379
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review