Smad4 (clone DCS-46), anti-human
€354.00
In stock
SKU
ARP-10-M1089
Catalog Number: 10-M1089
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4(SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Decription:
Mouse IgG monoclonal antibody for Smad4 (DPC4), SMAD family member 4 (SMAD4) detection. Tested with WB, ICC in Human. No cross reactivity with other proteins.
Synonyms: JIP, DPC4, MADH4, MYHRS, MAD homolog 4, MAD,mothers against decapentaplegic homolog 4(Drosophila), SMAD, mothers against DPP homolog 4(Drosophila), SMA- AND MAD-RELATED PROTEIN 4, DELETED IN PANCREATIC CARCINOMA 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4
Clone: DCS-46
Isotype: Mouse IgG1
Immunogen: Recombinant human Smad4(DPC4).
Reactivity: human
Form: Lyophilized; Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Applications: WB, ICC
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4(SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Decription:
Mouse IgG monoclonal antibody for Smad4 (DPC4), SMAD family member 4 (SMAD4) detection. Tested with WB, ICC in Human. No cross reactivity with other proteins.
Synonyms: JIP, DPC4, MADH4, MYHRS, MAD homolog 4, MAD,mothers against decapentaplegic homolog 4(Drosophila), SMAD, mothers against DPP homolog 4(Drosophila), SMA- AND MAD-RELATED PROTEIN 4, DELETED IN PANCREATIC CARCINOMA 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4
Clone: DCS-46
Isotype: Mouse IgG1
Immunogen: Recombinant human Smad4(DPC4).
Reactivity: human
Form: Lyophilized; Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Applications: WB, ICC
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
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