SMC1 (Phospho-S957) polyclonal, anti-human

Background:
The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein and Bamacan for the secreted proteoglycan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC3 is expressed as a nuclear protein in the colon, but can also occur as a secreted proteoglycan expressed in testis and brain. The secreted proteoglycan contains several glycosylation sites and is thought to play a role in basement membrane physiology.

Alternative Name:
SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, KIAA0178, MGC138332, OTTHUMP00000061876, RP6 29D12.1, SB1.8, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, SMC 1, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1, SMC1A, SMC1alpha, SMC1alpha protein, SMC1B, SMC1B, SMC1BETA, SMC1beta protein, SMC1L1, SMC1L2, SMCB, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, Structural maintenance of chromosomes protein 1B,

Application Dilution:
WB:1:1,000-1:5,000
IHC:1:50-1:200
ICC:1:50-1:200

Specificity: SMC1 (Phospho-S957) polyclonal antibody detects endogenous levels of SMC1 protein only when phosphorylated at S957.

Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1.

MW: 160 kDa

Swiss-Prot: Q14683(Human) Q8NDV3(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.