SMC1A Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13544a
Background:
Proper cohesion of sister chromatids is a prerequisite forthe correct segregation of chromosomes during cell division. Thecohesin multiprotein complex is required for sister chromatidcohesion. This complex is composed partly of two structuralmaintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2or the protein encoded by this gene. Most of the cohesin complexesdissociate from the chromosomes before mitosis, although thosecomplexes at the kinetochore remain. Therefore, the encoded proteinis thought to be an important part of functional kinetochores. Inaddition, this protein interacts with BRCA1 and is phosphorylatedby ATM, indicating a potential role for this protein in DNA repair.This gene, which belongs to the SMC gene family, is located in anarea of the X-chromosome that escapes X inactivation. [provided byRefSeq].
Other Names:
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13544a was selected from the N-term region of SMC1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SMC1A
Gene ID: 8243
Primary Accession: Q14683
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Proper cohesion of sister chromatids is a prerequisite forthe correct segregation of chromosomes during cell division. Thecohesin multiprotein complex is required for sister chromatidcohesion. This complex is composed partly of two structuralmaintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2or the protein encoded by this gene. Most of the cohesin complexesdissociate from the chromosomes before mitosis, although thosecomplexes at the kinetochore remain. Therefore, the encoded proteinis thought to be an important part of functional kinetochores. Inaddition, this protein interacts with BRCA1 and is phosphorylatedby ATM, indicating a potential role for this protein in DNA repair.This gene, which belongs to the SMC gene family, is located in anarea of the X-chromosome that escapes X inactivation. [provided byRefSeq].
Other Names:
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13544a was selected from the N-term region of SMC1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SMC1A
Gene ID: 8243
Primary Accession: Q14683
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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