SMURF1 Peptide
€100.00
In stock
SKU
350487
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Folding, Sorting and Degradation, Signal Transduction
Alternate Names: Smad ubiquitination regulatory factor 1; E3 ubiquitin-protein ligase SMURF1; Smad-specific E3 ubiquitin ligase 1; hSMURF1
Accession No.: Q9HCE7, NP_065162
Description:
SMURF1 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and directly transfers the ubiquitin to targeted substrates. SMURF1 interacts with receptor-regulated SMADs specific for the BMP pathway, SMAD1 and SMAD5, in order to trigger their ubiquitination and degradation.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 1781.9 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200125 is selected from a sequence within the center region of human SMURF1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C72H120N26O25S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease: Folding, Sorting and Degradation, Signal Transduction
Alternate Names: Smad ubiquitination regulatory factor 1; E3 ubiquitin-protein ligase SMURF1; Smad-specific E3 ubiquitin ligase 1; hSMURF1
Accession No.: Q9HCE7, NP_065162
Description:
SMURF1 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and directly transfers the ubiquitin to targeted substrates. SMURF1 interacts with receptor-regulated SMADs specific for the BMP pathway, SMAD1 and SMAD5, in order to trigger their ubiquitination and degradation.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 1781.9 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200125 is selected from a sequence within the center region of human SMURF1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C72H120N26O25S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
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