SMYD1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8829
Background:
SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development.
Alternative Name:
CD8 beta opposite zinc finger, MYND domain containing 18, BOP, KMT3D, ZMYND18, ZMYND22, SMYD1
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: SMYD1 polyclonal antibody detects endogenous levels of SMYD1 protein.
Immunogen:
Recombinant full length Human SMYD1.
MW: ~ 57kDa
Swis Prot.: Q8NB12
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development.
Alternative Name:
CD8 beta opposite zinc finger, MYND domain containing 18, BOP, KMT3D, ZMYND18, ZMYND22, SMYD1
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: SMYD1 polyclonal antibody detects endogenous levels of SMYD1 protein.
Immunogen:
Recombinant full length Human SMYD1.
MW: ~ 57kDa
Swis Prot.: Q8NB12
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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