SNAI2 (clone 2H5), anti-human

Background:
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in gamma-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Research Area: Neuroscience, Cancer, Stem cells, Epigenetics and nuclear signaling, Developmental biology

Synonyms: SLUG, WS2D, SLUGH1, MGC10182, SNAI2

Immunogen: Purified recombinant fragment of human SNAI2 expressed in E. Coli.

Formulation: Ascitic fluid containing 0.03% sodium azide.

Storage:
4°C|-20°C for long term storage