Snail1 (phospho-S246) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4606
Background:
The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3.
Alternative Name:
Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH, SNAI 1, Snail 1, Snail-1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Snail1 (phospho-S246) polyclonal antibody detects endogenous levels of Snail1 protein only when phosphorylated at Ser246.
Immunogen:
Synthetic peptide, corresponding to amino acids 211-260 of Human Snail1.
MW: ~ 29 kDa
Swis Prot.: O95863
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3.
Alternative Name:
Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH, SNAI 1, Snail 1, Snail-1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Snail1 (phospho-S246) polyclonal antibody detects endogenous levels of Snail1 protein only when phosphorylated at Ser246.
Immunogen:
Synthetic peptide, corresponding to amino acids 211-260 of Human Snail1.
MW: ~ 29 kDa
Swis Prot.: O95863
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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