SOCS3 antibody (clone 10000), anti-human

Background:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Other Names:
Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3, SOCS3, CIS3, SSI3

Antigen Type:
Recombinant Protein

Gene Name: SOCS3 (HGNC:19391)
Gene ID: 9021
NCBI Accession: NP_003946.3
Primary Accession: O14543
Other Accession: BC060858
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .