SOCS3 monoclonal (Ascites), anti-human
€470.00
In stock
SKU
AC-AM2154a
Catalog Number: AC-AM2154a
Size: 100 µl
Isotype: mouse IgM
Clone Name: 532CT13.5.3
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgM
Clone Name: 532CT13.5.3
Applications: WB
Datasheet
Request Information
Background:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Other Names:
Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3, SOCS3, CIS3, SSI3
Target/Specificity:
This SOCS3 Antibody is generated from mouse immunized with recombinant protein of human SOCS3.
Antigen Type: Recombinant Protein
Gene Name: SOCS3 (HGNC:19391)
Gene ID: 9021
Primary Accession: O14543
NCBI Accession: NP_003946.3
Other Accession: NP_003946.3
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Other Names:
Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3, SOCS3, CIS3, SSI3
Target/Specificity:
This SOCS3 Antibody is generated from mouse immunized with recombinant protein of human SOCS3.
Antigen Type: Recombinant Protein
Gene Name: SOCS3 (HGNC:19391)
Gene ID: 9021
Primary Accession: O14543
NCBI Accession: NP_003946.3
Other Accession: NP_003946.3
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
| Is Featured? | No |
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