SOD1 (clone 6F5), anti-human, mouse

Protein Family: Enzymes

Pathway and Disease: Signaling Molecules and Interaction, Neurodegenerative Disorders

Description:
SOD1 (Superoxide dismutase 1) destroys free radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 catalyzes the following reaction: 2 superoxide + 2 H+ = O2 + H2O2. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.

Alternate Names: Superoxide dismutase [Cu-Zn], SOD1, Superoxide dismutase-1

Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400;

Accession No.: P00441

Antigen: Purified recombinant fragment of human SOD1 expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.