Sonic Hedgehog SHH monoclonal, anti-human

Description: Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Protein Function:
Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity)..

Other Names: Sonic hedgehog protein, SHH, 3.1.-.-, HHG-1, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhNC, Sonic hedgehog protein N-product, ShhN, Shh N-terminal processed signaling domains, ShhNp, SHH (HGNC:10848)

Clone Name(s):
Clone: ABE-19

Subcellular Localization: Sonic hedgehog protein C-product: Secreted, extracellular space. The C-terminal peptide diffuses from the cell..

Tissue Specificity: Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.

Gene ID: 6469

Immunogen: A synthesized peptide derived from human Sonic Hedgehog

Calculated MW: 49607

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.