SOST Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP6261a
Background:
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Other Names:
Sclerostin, SOST
Target/Specificity:
The synthetic peptide sequence is selected from aa 27-42 of HUMAN SOST
Gene Name: SOST (HGNC:13771)
Gene ID: 50964
Primary Accession: Q9BQB4
Other Accession: Q99P68, Q99P67, Q9BG79
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Other Names:
Sclerostin, SOST
Target/Specificity:
The synthetic peptide sequence is selected from aa 27-42 of HUMAN SOST
Gene Name: SOST (HGNC:13771)
Gene ID: 50964
Primary Accession: Q9BQB4
Other Accession: Q99P68, Q99P67, Q9BG79
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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